2. METHODS
2.1. Methods
Recommendation within the Guidelines are developed by the panels to prioritise clinically important care decisions. The strength of each recommendation is determined by the balance between desirable and undesirable consequences of alternative management strategies, the quality of the evidence (including certainty of estimates), and the nature and variability of patient values and preferences. This decision process, which can be reviewed in the strength rating forms which accompany each guideline statement, addresses a number of key elements:
- the overall quality of the evidence which exists for the recommendation [4];
- the magnitude of the effect (individual or combined effects);
- the certainty of the results (precision, consistency, heterogeneity and other statistical or study-related factors);
- the balance between desirable and undesirable outcomes;
- the impact and certainty of patient values and preferences on the intervention
Strong recommendations typically indicate a high degree of evidence quality and / or a favourable balance of benefit to harm and patient preference. Weak recommendations typically indicate availability of lower quality evidence, and/or equivocal balance between benefit and harm, and uncertainty or variability of patient preference [5].
Additional information can be found in the general Methodology section of this print, and online at the EAU website: https://uroweb.org/guidelines/urolithiasis/publications-appendices. A list of associations endorsing the EAU Guidelines can also be viewed online at the above address.
2.2. Review
The 2015 Urolithiasis Guidelines were subjected to peer review prior to publication. Chapter 6, detailing the treatment and follow-up of bladder stones was peer-reviewed in 2019.